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-24th April 2015

Mirada Medical presents research results on the clinical utility of Deformable Image Registration and exhibits latest software at 3rd ESTRO forum 2015

Mirada Medical presents research results on the clinical utility of Deformable Image Registration and exhibits latest software at 3rd ESTRO forum 2015. Oxford, United Kingdom, 23rd April 2015: State-of-the-art Deformable Image Registration and multi-modality imaging techniques continue to drive advances in Radiation Therapy clinical practice. Novel research into the utility and benefit of such advanced techniques are the topics that the Mirada Medical scientific team and collaborators will be presenting at the 3rd ESTRO forum conference this week in Barcelona, Spain.

The first study, entitled “The potential role of diagnostic position MRI with deformable registration for radiotherapy planning of HNSCC”, is in collaboration with Leeds St. James Hospital (UK). This study examined the use of MRI acquired in diagnostic position that are fused to the planning CT using Mirada CT-MR Deformable Image Registration (Mirada RTx, Mirada Medical, UK), and the consequent effects on contouring accuracy and intra-observer variability. Accurate target and organs-at-risk structures are a prerequisite for effective radiation treatment. The study compared a number of planning structures in Head and Neck squamous cell carcinoma patients drawn on the planning CT alone, diagnostic MRI alone and planning MRI alone. The results showed that the Gross Tumour Volume (GTV) accuracy improved markedly when using the diagnostic MRI, and intra-observer variability reduced.

The second study, entitled “Fractionation-corrected doses with deformable registration as a tool for treatment plan comparison”, is in collaboration with Tampere University Hospital (Finland). It examines the role of Mirada CT-CT Deformable Image Registration (Mirada RTx, Mirada Medical, UK) in the task of decision making for patients with recurrent disease. The study presents a framework for evaluating the dose to organs-at-risk when considering multiple treatments and compares the results when performing raw dose summation and biological dose summation - both with and without healing. Importantly, the critical step of registration quality assessment is discussed, requiring the assessment of both the image fusion and the deformation field to ensure biological plausibility.

The details of the studies are: The potential role of diagnostic position MRI with deformable registration for radiotherapy planning of HNSCC R. Speight, J. Sykes, M. Gooding, A. Larrue, A. Scarsbrook, R. Prestwich Abstract number: OF3-1244. Fractionation-corrected doses with deformable registration as a tool for treatment plan comparison E. Boman, L. Pickup, M. Kapanen, T. Kadir Abstract number: OF3-0436.   Mirada Medical will be demonstrating their complete suite of radiotherapy software applications including RTx and Workflow Box, on their booth #3100 at ESTRO. The researchers will be available to discuss their research and answer questions.

For more information, please contact:

Mirada Medical

US/Worldwide: Kranti Parekh

enquiries@mirada-medical.com

www.mirada-medical.com

World Headquarters:

Oxford Centre for Innovation

New Road,

Oxford OX1 1BY

United Kingdom

Tel: +44(0)1865 261410ical Ltd.